Excerpt from The Coagulation of Blood: Dissertation Submitted to the Board of University Studies of the Johns Hopkins University in Conformity With the Requirements for the Degree of Doctor of Philosophy
Recent investigators of the phenomenon of blood coagula tion have come to rather widely divergent conclusions. Morawitz(1) attempting to harmonize the older views of Schmidt, with the later work of Pekelharing, Hammarsten and others, gives four factors entering into the process. Three of these pre-exist in the circulating blood; the fibrinogen, the thrombogen or proferment, and the salts of calcium. The fourth factor arises at the moment of coagulation, and is produced by the disintegration of the formed elements of the blood-the platelets and probably also the leucocytes.
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