The American Journal of Syphilis, Vol. 1: January, April, July, October, 1917 (Classic Reprint) - Hardcover

Inhaltsangabe

Excerpt from The American Journal of Syphilis, Vol. 1: January, April, July, October, 1917

Kolle and Rothermundt11 regarded chicken spirillosis as a favor able experimental infection to work with. Known mercurials which possess value in the treatment of syphilis, exhibit a favorable in fluence in chicken spirillosis. This fact makes the infection with the spirocheta gallinarum a good test for the determination of the value of new mercurial compounds. Experiments with Asurol, dinitro mercuri-diphenyl-carboxylic acid and other new synthetic mercury compounds, demonstrated that they were not superior to any of the known preparations. The working hypothesis advanced by Blumen thal, that therapeutically active mercurial compounds must possess an affinity for liver cells, and the opinion of Schrauth and Schoeller concerning the necessity of mercury being firmly attached to the or ganie molecule in half complex form, were not concurred in by the authors; they invoked data based upon actual experimentation in support of their adverse views. They held that the therapeutic value of a mercurial preparation bore no relationship to the firm ness of mercury in the molecule nor to the fact that the compound was a precipitant for protein, nor to the solubility or insolubility of the compound. The establishing of the therapeutic index was re garded by them as most important; i. E., the relationship of the dosis lethalis to the dosis therapeutica, as proposed by Ehrlich.

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