Defective binding of a PPARG and STAT1 complex to the CD36 promotor is implicated in a familial disorder which can cause autoinflammatory symptoms, connective tissue symptoms and psychosis. - Softcover

Inhaltsangabe

The binding of a PPARG and STAT1 complex to the STAT binding site at -107 nucleotides in the CD36 promotor is identified as an interaction which very directly links to the main genes and metabolic pathways previously implicated in a familial disorder, suggesting that defective binding of this PPARG and STAT1 complex to the CD36 promotor should play a central role in the aetiology of the familial disorder. The same interaction may be of significance in autoinflammatory disorders more generally.

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