Neurobiology of Mental Illness

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9780195149623: Neurobiology of Mental Illness

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.
For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

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About the Author:

Dennis S. Charney is at NIMH. Eric J. Nestler is at University of Texas, Southwestern Medical Center, Dallas.


"The second edition of Neurobiology of Mental Illness...stands as a superb contribution to the understanding of neurobiological bases of mental disorders. It is a highly readable, well-organized text. Anyone interested in the neurobiological underpinnings of psychiatric conditions would be well served to have this text on hand, both for casual browsing and for in-depth study." --The Journal of Nervous and Mental Disease

"The chapters are clearly and consistently written and attractively presented. This volume embodies a thoroughgoing materialism." -Cognitive Neuropsychiatry

Praise for the First Edition:

"Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds." --JAMA

". . . well-written, neatly organized, and synthetic . . . a text of this sort is a requisite for any modern psychiatry residency curriculum . . . Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds."--Steven J. Siegel, MD, PhD, in JAMA

"The authors are uniformly first rate...The discipline described here is a far cry from the psychiatry we grew up with. Sigmund Freud, a neurobiologist by training, would have been proud."--J.L. Numberger Jr., in The New England Journal of Medicine

"The editors deserve tremendous credit for compiling a most useful reference text, and I am not aware of a similar textbook that is anywhere as comprehensive, up-to-date, or focused on the basic science of our field. I think this book would be an excellent resource for psychiatric residents, early doctoral students in neurochemistry and the neurosciences, and psychiatric researchers interested in the basic underpinnings of mental disorders."--David L. Dunner in The American Journal of Psychiatry

" excellent book, well written and well edited...and packed with information. I found it thought-provoking and intensely educational."--Tim Betts in Brain

"The book provides a well-written, neatly organized, and synthetic middle ground between a more comprehensive text of clinical psychiatry, as provided in Synopsis of Psychiatry...and basic neuroscience texts, such as Principles of Neuroscience..." JAMA

"...the best account to date of the neurobiology of mental disorders. It is an excellent source of reference but many of the chapters provide very good conceptual overviews that well deserve to be read as introductions to the field. A book to dip into for pleasure, as well as one to turn to in order to find out what is known on a particular topic."--Sir Michael Rutter in Trends in Neuroscience

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