Cardiac Contraction and the Pressure-Volume Relationship

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9780195043204: Cardiac Contraction and the Pressure-Volume Relationship

The product of 15 years of intense collaborative research, this book explains the use of the pressure-volume diagram in evaluating cardiac performance. This approach has gained increasingly widespread acceptance since the mid-1970s. It is an extremely useful way to understand the fundamental mechanics of cardiac contraction and its interaction with the vascular system. After a brief historical overview, the authors describe the similarities between the ventricular pressure-volume relationship and the muscle tension-length relationship. The effect of various physiological mechanisms and pharmacological interventions are examined, as are the energetics of ventricular contractions and the hemodynamics of the entire circulatory system. Clinical applications are considered and current knowledge about the effects of growth and aging is reviewed. The authors provide necessary explanatory information from physics and engineering to allow a full understanding by clinicians and physiologists. The book will be of particular interest to cardiologists, cardiovascular physiologists and bioengineers.

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About the Author:

Lowell Maughan, Associate Professor, Division of Cardiology, both at the Johns Hopkins University School of Medicine. Hiroyuki Suga, Director, Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka.


"A milestone in cardiac physiology. I think I am safe in saying that there has never been a book that addressed so adequately both the very, very basic principles of cardiac contraction while at the same time fitting the heart into the total system. Therefore I feel certain that the book
will be both widely used and widely respected throughout the entire cardiovascular community." -- Arthur C. Guyton, M.D., University of Mississippi Medical Center

"This book represents a comprehensive, up-to-date treatise on P-V relationship studies. In their evaluation of the various models of cardiac contraction the authors always carefully point out the advantages as well as the limitations so as to avoid any overestimation of the data. The
references are properly cited, especially those from early stage P-V loop studies. . . . the volume as a whole is highly recommended." -- Canadian Journal of Cardiology

"An authoritative review of cardiac performance based on analysis in the pressure-volume plane. . . .the strength of the book lies in the skillful integration of extensive experimental findings into a cohesive conceptual approach to evaluate and describe left ventricular performance. This
book will be of considerable value to those interested or involved in learning and teaching cardiovascular physiology, and to anyone interested in investigative and clinical evaluation of left ventricular performance." --Chest

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