The Chlamydomonas Sourcebook: Volume 3: Cell Motility and Behavior (Chlamydomonas Sourcebooks, 3) - Hardcover

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Susan K. Dutcher is a professor and the former director of the McDonnell Genome Institute at Washington University School of Medicine. She earned her PhD at the University of Washington in Seattle, where her thesis work focused on the role of cell division cycle genes in karyogamy in S. cerevisiae with Dr. Leland Hartwell. In 1980, she began work on Chlamydomonas basal bodies and cilia at Rockefeller University. She was a faculty member at the University of Colorado, Boulder from 1983 to 1999. Her lab investigates the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology in Chlamydomonas as well as human tissue culture cells. Key questions addressed in her research are how these microtubule-based structures are assembled, how they are regulated with respect to the cell cycle, and how they function and influence cellular biology, development, and human health. Stemming from the lab’s comparative genomics work in 2004, the discovery of many cilia and centriole-based diseases has illustrated the incredible breath of roles that these organelles play in human health. She is a fellow of the American Academy of Arts and Sciences, the American Society of Cell Biology, and the American Association for the Advancement of Science. She has had key collaborations with numerous scientists.

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Originally published as the Chlamydomonas Sourcebook, then expanded to a three volume comprehensive gold-standard reference, The Chlamydomonas Sourcebook Volume 3: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community.

Representing the latest advances in the area from an international array of expert authors, reflecting the significant advancement in the understanding of the role of basal bodies and flagella in human diseases. In addition, employing quantitative proteomics/mass spectroscopy as well as cryo EM tomography and single particle cryo EM has revolutionized our knowledge of the axoneme in terms of the location of proteins and their interactions. Current insights on mitosis and cytokinesis; flagellar assembly and motility; intraflagellar transport, and more will ensure use of this reference as a guide for understanding human diseases of the cilium. The volume will be an essential source for all students and researchers interested in cell motility.