Clinical Bioenergetics: From Pathophysiology to Clinical Translation - Softcover

Über die Autorin bzw. den Autor

Dr. Sergej M. Ostojic is a full professor of nutrition at the University of Agder and the University of Novi Sad. His current research follows two main themes: studying mitochondrial viability and targeted nutritional interventions to tackle impaired bioenergetics in health and disease, and analyzing population health metrics in chronic cardiometabolic diseases. To date, he has authored and coauthored over 280 peer-reviewed research and review articles in high-impact journals, such as The Lancet, Nature, The BMJ, Trends in Food Science and Technology, Trends in Endocrinology and Metabolism, Advances in Nutrition, Mayo Clinic Proceedings, Clinical Nutrition, Pharmacological Research, Nutrients, European Journal of Nutrition, and Nutritional Neuroscience. He is a member of the American College of Physicians, the American Society for Nutrition, the American Physiological Society, the International Society for Cerebral Blood Flow and Metabolism, and the Nutrition Society, and has been the recipient of internationally competitive research grants including the WADA Scientific Research Grant, NSCA International Award, and the European Commission, and many industrial endowments. Dr. Ostojic holds eight patents and patent applications in the United States, United Kingdom, European Union, and Japan.

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Mitochondrial energy shortfall has long been considered an important agent across a range of clinical pathologies - from inherited disorders that affect energy metabolism to intoxications, cardiometabolic and neurodegenerative diseases. Bioenergetics - the study of the transformation of energy in living organisms - stands as a growing, innovative discipline tackling functional aspects of energy metabolism in biological processes and disease.

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides an in-depth view of recent developments in understanding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Early foundational chapters offer a strong basis in foundational aspects of bioenergetics and disease, including the omics landscape of impaired mitochondrial bioenergetics; and hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others.