Pan-genomics: Applications, Challenges, and Future Prospects - Softcover

Über die Autorinnen und Autoren

Dr. Debmalya Barh is currently a Visiting Full Professor (Titular, Grade-E) in Bioinformatics and Precision Health at the Department of Genetics, Ecology, and Evolution, ICB, Federal University of Minas Gerais, Brazil and honorary scientist of the Institute of Integrative Omics and Applied Biotechnology (IIOAB), India. With over 20 years of experience, he has led academic, healthcare, molecular diagnostic, and bioinformatics industry endeavors. He works with more than 400 scientists from 100+ top ranked organizations across 40+ countries and has 220+ publications and a branded editor for 10+ cutting-edge omics related reference books. He is an expert in in precision/personalized health and integrative omics-based biomarker and target discovery in infectious and complex lifestyle diseases.

Dr Soares holds a degree in Biomedicine, with special training in Bioinformatics, Master's Degree and PhD in Genetics by Federal University of Minas Gerais – UFMG, the latter with one year of study at the Center for Biotechnology (CeBiTec), Universität Bielefeld. He holds a Post-doctorate in Bioinformatics by UFMG. He was Senior Researcher Bioinformatics at the Central Official Laboratory of the Brazilian Ministry of Fisheries and Aquaculture (2014-2015). He is currently Professor at Federal University of the Triângulo Mineiro (UFTM) since 2015, Secretary of the Southeastern regional of the Brazilian Society of Genetics (2017-current), Substitute Coordinator of the undergraduate course in Biomedicine at UFTM (2017-current) and Substitute Research and Technology Development Coordinator of UFTM (2017-current). His research interests are molecular genetics, genomic sequencing and comparative genomics of microorganisms, focusing on pan-genomics, genomic plasticity in the identification of islands of pathogenicity and virulence factors, phylogenomics, molecular epidemiology, reverse vaccination and software development.

Dr. Tiwari obtained his BSc from Deen Dayal Upadhyaya Gorakhpur University, MSc in bioinformatics from Devi Ahilya University, and PhD in bioinformatics from the Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Brazil. He is a Guest Associate Editorial Board of Frontier in Genetics and frequently serves as an external reviewer for PeerJ and Frontiers. His main areas of expertise are molecular genetics, genomic sequencing, and comparative genomics of microorganisms, with a focus on pan-genomics, genomic plasticity in the identification of pathogenicity islands and virulence factors for drug discovery, phylogenomic, molecular epidemiology, reverse vaccinology, and immunoinformatic.

Dr. Vasco Azevedo is a full professor at the Department of Genetics, Ecology, and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. He is a CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) researcher 1A, member of the Brazilian Academy of Sciences, Commander of the Order of Scientific Merit of the MCTI of the genetics advisory committee and the public policy working group on biotechnology and genetic resources of COBRG/CNPq, coordinator of the Associated International Laboratory Bactinfl from INRAE and UFMG, and vice-president of the Brazilian Association of Bioinformatics and Computational Biology. He holds a degree in veterinary medicine from the School of Veterinary Medicine of the Federal University of Bahia (1986), a master's degree (1989), a doctorate (1993) in the genetics of microorganisms from the Institut National Agronomique Paris Grignon, and a doctorate in bioinformatics from UFMG (2017). He did his postdoctorate work with the Department of Microbiology, School of Medicine, University of Pennsylvania, United States (1994). He was a professor at the Institute of Biomedical Sciences of the University of São Paulo (2004). He is an expert in genetics and bioinformatics and his work mainly focuses on genomics, transcriptomics, proteomics, metabolomics, vaccine development, diagnostics, and the development of next generation probiotics. He has more than 600 scientific publications, 14 books, and 60 chapters as well as 12 patents.

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Pangenomics and the evolution of bacteria: an overview of current approaches, challenges and future prospects is a detailed work on the current approaches and future applications of pangenomics. It covers the bioinformatics tools as well as their applications, and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms.

The book is divided in three sections: the first, “Overview of pangenomics and common approaches”, brings the main concepts and current approaches on pangenomics research; the second, “Case studies in pangenomics”, discusses through twelve case studies the tools applied and the results gathered; and the last, “Current approaches and future prospects in pan-multiomics”, encompasses the developments on omics studies to be applied on bacteria related studies.

This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relation with human health.