Nutritional Epigenomics: Volume 14 (Translational Epigenetics, Volume 14) - Softcover

Über die Autorin bzw. den Autor

Bradley S. Ferguson is an Associate Professor of Nutrition at the University of Nevada, Reno, Nevada. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how sarcomere protein acetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and skeletal muscle dysfunction. Dr. Ferguson has published his findings across a wide range of peer-reviewed journals, including Scientific Reports, Journal of Animal Science, American Journal of Physiology, Cell Reports, PNAS, and the Journal of Molecular and Cellular Cardiology.

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Over the last decade, interest in diet-gene interactions has led researchers to examine epigenomic reprogramming and nutritional intervention in the treatment and prevention of disease. These studies, in part assisted with technological advances in epigenomic sequencing, have increased our understanding of diet’s influence over epigenetic regulation in aging, fetal growth and development, transgenerational inheritance, and circadian rhythm, in addition to health and disease.

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, and current understanding of nutrition’s role in epigenomic regulation of disease, health, and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are discussed as well, as are the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors also examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.

Throughout Nutritional Epigenomics, close attention is paid not only to recent findings of translational significance, but epigenomic approaches, technologies, and modes of analysis to enable future epigenomic studies