Transgenerational Epigenetics: Evidence and Debate (Translational Epigenetics, Volume 13) - Softcover

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Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

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Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather reversible and heritable epigenetic processes. These processes may have selective or adverse effects on offspring persisting for multiple generations.

Transgenerational Epigenetics, Second Edition offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with emphasis on human disease relevance, drug discovery, and next steps in clinical translation. Here, international experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease, are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent disease before the offspring are born, or reduce the severity of disease at the very earliest stages of development in utero.

This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as well as current debates and future directions for research.