The Complement FactsBook - Softcover

Über die Autorin bzw. den Autor

Scott Barnum received his B.S. in Biology (cum laude) from Loyola University in Maryland and his Ph.D. from the University of Alabama at Birmingham where he worked on the biosynthesis of factor D for his thesis studies. He then pursued postdoctoral studies on the genomic organization of several complement genes in the Department of Immunology at the Scripps Research Institute. He returned to UAB as a member of the faculty in the Department of Microbiology and holds secondary appointments in the Department of Neurology and the Division of Clinical Immunology and Rheumatology. Since returning to UAB, Dr. Barnum’s research has focused primarily on the role of complement in the central nervous system. Through a combination of in vitro and in vivo studies, his lab demonstrated that glia cells and neurons produce a variety of complement proteins and receptors. Subsequently, the lab identified the role of complement in numerous animal models of human disease including, traumatic brain injury, multiple sclerosis, bacterial meningitis, stroke, and cerebral malaria. In addition to numerous teaching awards, he produced the first high quality animated videos for teaching complement activation and biological functions. Dr. Barnum is currently working on the development of complement diagnostics for use in a variety of infectious disease and autoimmune indications.

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How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?

The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'A growing series of excellent manuals' by Molecular Medicine Today, and 'Essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. Meticulously researched and compiled by experts in the field, keeping abreast of developments has never been so easy!

The Complement FactsBook contains entries on all the components of the Complement system, including C1q and Collectins, C3 Family Proteins, Serine Proteases, Regulators of Complement Activation, Cell Surface Receptors and Terminal Pathway proteins.

Entries provide information on:

• alternative nomenclature
• physiochemical properties
• structure & function
• tissue distribution & regulation of expression
• protein sequence/modules
• chromosomal location
• cDNA sequence and intron-exon boundaries
• genomic structure
• database accession numbers
• deficiency & polymorphic variants
• key references