Complement Regulatory Proteins - Hardcover

Über die Autorin bzw. den Autor

Dr. Harris is in the Complement Biology Group, Department of Medical Biochemistry, University of Wales College of Medicine. Her Ph.D. degree was in Professor Peter Lachmann’s unit in Cambridge where, under the supervision of Dr. Richard Harrison, she undertook studies of the biochemistry of C3. She completed her Ph.D. in 1993. She retains a strong interest in the biochemical aspects of the complement system and in the regulators which control complement at the level of C3.

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The Complement System provides a powerful defense against invading organisms, but the cascade system, which generates a variety of cytotoxic and cytolytic products is a potential danger to our own cells. The Complement System therefore needs to be carefully, and tightly regulated.

The study of Complement regulatory proteins has undergone an information explosion over the last decade. Fueled by the discovery of new regulators, the cloning and discovery of structural and evolutionary links between them. It has also been motivated by the development of recombinant forms for use in therapy.

The time is therefore ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that.

• Complement regulators--structure, functional roles and mode of action
• Comprehensive reviews of each of the individual regulators
• Roles of Complement regulators in vivo, in health and disease
• consequences of deficiency
• roles in the reproductive system
• interactions with pathogens and
• exploitation for therapy
• Complement regulators in other species

This is a young and growing area which will undoubtedly contribute to the future understanding and therapy of disease.Written in a readable, engaging manner, and extensively referenced -- with nearly 2000 citations -- the authors' enthusiasm for the subject will be infectious!