Verwandte Artikel zu Single Molecule Biology

Single Molecule Biology - Hardcover

 
9780123742278: Single Molecule Biology
Hardcover
ISBN 10: 0123742277 ISBN 13: 9780123742278
Verlag: Academic Press, 2008

Inhaltsangabe

Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery.

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Single molecule techniques are powerful tools for the dissection of biological function. They can be used to investigate the mechanisms of molecular machines, wind up single strands of DNA, or unravel individual proteins. They can detect the flickering open of an ion channel in a membrane or watch an enzyme turn over a molecule of substrate.

This book reveals how single molecule techniques have revolutionized our understanding of biology at the nanoscale―and it is the first book to be focused on the biology, rather than the techniques themselves. As such, it is targeted at biologists and a broad interdisciplinary readership.

Each chapter in this multicontributed book is written by an expert in the field, covering a key biological system studied by single molecule methods, and exploring what has been learnt from this new approach. Systems examined include molecular motors (kinesin, dynein, myosin, and the bacterial flagellar motor); nucleic acids (chromatin, DNA-based enzymes, and the ribosome); membranes and ion channels; and a look at applications to microarray technology.

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Verlag
Academic Press
Erscheinungsdatum
2008
Sprache
Englisch
ISBN 10 
0123742277
ISBN 13 
9780123742278
Einband
Gebundene Ausgabe
Anzahl der Seiten
368
Herausgeber
Knight Alexander E.
Kontakt zum Hersteller
Nicht verfügbar
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