Key Heterocycle Cores for Designing Multitargeting Molecules - Softcover

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Dr. Om Silakari is an assistant professor in the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India. He received his Ph.D. degree from Dr. Hari Singh Gour University, India and has been teaching and researching in this area for over 10 years. His research areas include computer-assisted drug designing (CADD) of new anti-inflammatory, antidiabetic and anticancer targets, and the synthesis of new lead molecules. In addition to supervising multiple M. Pharm. and PhD students, he has authored two books and published over 60 papers in international journals. Dr Silakari is an active reviewer for many international journals, has been awarded funding for several research projects, and regularly delivers talks at both national and international conferences.

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A review of advances in the adaptation of heterocyclic nuclei for the development of multi-target drugs

• Emphasizes the chemical development of heterocyclic nuclei from single to multi-targeting molecules

• Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multi-targeting agents

• Outlines current trends and future developments in multi-target molecule design for the treatment of various important diseases.

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the area of multi-targeting molecules. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multitargeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.

Key Heterocycle Cores for Designing Multitargeting Molecules covers the manipulation of heterocycle cores for the development of dual or multi-targeting molecules, and goes on to describe specific examples of such developments, focusing on compounds including Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline.

Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets.

Dr. Om Silakari is an Assistant Professor in the Department of Pharmaceutical Sciences and Drug Research, Punjab University, India. His main research areas include computer-assisted drug designing (CADD) of new anti-inflammatory, antidiabetic and anticancer targets, and the synthesis of new lead molecules.