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Hardcover. Zustand: Gut. XXII, 369 p.: Ill. Lediglich der Einband weist leichte Gebrauchsspuren auf, sonst ein gutes und sauberes Exemplar ohne Anstreichungen / Only the cover shows slight signs of use, otherwise a good and clean copy without markings. - CONTENTS I Background 1. HISTORY OF LANDRY-GUILLAIN-BARRÉ-STROHL SYNDROME EARLY DESCRIPTIONS AND LANDRY S CONTRIBUTION . . GUILLAIN, BARRE, AND STROHL REFINEMENTS AFTER THE SEMINAL ARTICLE FISHER S SYNDROME AND VARIANTS THE "GUILLAIN-BARRE" EPONYM PATHOLOGIC BASIS OF THE SYNDROME MODERN IMMUNOLOGIC AND ELECTROPHYSIOLOGIC BASIS OF THE SYNDROME TREATMENTS PERSONAL ACCOUNTS 2. DIAGNOSTIC CRITERIA PROPOSED CRITERIA 3. EPIDEMIOLOGY DEMOGRAPHIC FEATURES Incidence, Age, and Sex Distribution Geographic and Racial Distribution Outbreaks of GBS Seasonal Variation Occupational Distribution HLA Association THE "SWINE FLU" GBS ISSUE FAMILIAL GBS OTHER POTENTIAL RISK FACTORS . II Neurobiologic Basis of Guillain-Barre Syndrome 4. PATHOLOGY THE INFLAMMATORY REACTION DISTRIBUTION OF INFLAMMATORY LESIONS DEMYELINATION AND AXONAL LESIONS LATE LESIONS AND REPARATIVE PROCESSES LESIONS OF THE CENTRAL NERVOUS SYSTEM NERVE AND MUSCLE BIOPSY ELECTRON MICROSCOPIC FEATURES 5. IMMUNOLOGY ANIMAL DISEASES THAT SIMULATE GBS Coonhound Paralysis Marek s Disease Cauda Equina Neuritis of Horses EXPERIMENTAL ALLERGIC NEURITIS (EAN) Myelin Antigens in EAN Effects of Immunosuppression in EAN GALACTOCEREBROSIDE-INDUCED DEMYELINATION IMMUNE MECHANISMS IN GBS Cell-Mediated Immune Response Antibody-Mediated Immune Response SUMMARY OF THE IMMUNOPATHOGENESIS OF GBS Ill Clinical Features of Guillain-Barre Syndrome 6. ANTECEDENT AND ASSOCIATED ILLNESS VIRAL INFECTIONS Influenza Herpes Virus Hepatitis HIV and AIDS Other Viruses BACTERIAL INFECTIONS Campylobacter Jejuni Mycoplasma Pneumonia Spirochetal Infections Other Bacteria VACCINATION SYMPTOMATIC GBS Cancer and Lymphoma Autoimmune and Collagen-Vascular Disease Sarcoidosis ENDOCRINE DISORDERS GBS AND PREGNANCY SURGERY AND SPINAL EPIDURAL ANESTHESIA UNCERTAIN ASSOCIATIONS 7. CLINICAL FEATURES OF THE TYPICAL SYNDROME FREQUENCY OF THE MAJOR FEATURES IN TYPICAL GBS PATTERN OF WEAKNESS . PARESTHESIAS AND SENSORY LOSS DIMINISHED TENDON REFLEXES PAIN PROGRESSION OF GBS UNUSUAL CLINICAL FEATURES IN OTHERWISE TYPICAL CASES OPHTHALMOPLEGIA AND OTHER OCULAR SIGNS Eye Movement Abnormalities Pupillary Abnormalities Lid Abnormalities Pathology in Cases with Ophthalmoplegia Optic Neuritis Papilledema and Pseudotumor Cerebri DYSAUTONOMIA Hypertension Hypotension and Orthostatic Hypotension Sinus Tachycardia Vagal Spells Other Arrhythmias Bladder Dysfunction Gastrointestinal Dysfunction Abnormal Drug Responses Neurogenic Pulmonary Edema Lacrimal and Salivary Function Pupillary and Accommodation Abnormalities Sexual Dysfunction Temperature, Sweating, and Vasomotor Regulation Bronchial Smooth Muscle Dysfunction 8. VARIANT SYNDROMES PURE MOTOR GBS SENSORY GBS PURE PANDYSAUTONOMIA i PHARYNGEAL-CERVICAL-BRACHIAL WEAKNESS PARAPARETIC WEAKNESS FISHER'S SYNDROME The Clinical Syndrome Cerebellar Ataxia without Ophthalmoplegia Electrophysiology in Fisher's Syndrome Central Versus Peripheral Origin of Signs in Fisher's Syndrome and Autopsy Pathology Treatment of Fisher s Syndrome 9. GUILLAIN-BARRE SYNDROME IN CHILDREN PRECEDING INFECTION CLINICAL FEATURES DIFFERENTIAL DIAGNOSIS LABORATORY AND ELECTROPHYSIOLOGIC FINDINGS PROGNOSIS MANAGEMENT 10. RELAPSING AND CHRONIC INFLAMMATORY POLYNEUROPATHY EARLY RELAPSES WITHOUT CHRONIC PROGRESSION (BIPHASIC ACUTE GBS) RELAPSING ACUTE GBS SEPARATED BY LONG ASYMPTOMATIC INTERVALS CHRONIC INFLAMMATORY DEMYELINATING POLY NEUROPATHY (CIDP) CIDP Beginning as Acute GBS CIDP with Subacute Onset (Typical CIDP) CIDP in Children Laboratory Findings Pathology Treatment Differential Diagnosis 11. SYSTEMIC DISORDERS RESULTING FROM GUILLAIN-BARRE SYNDROME CARDIAC INVOLVEMENT RENAL INVOLVEMENT GASTROINTESTINAL AND HEPATIC INVOLVEMENT ENDOCRINE DISTURBANCES Syndrome of Inappropriate ADH Secretion (SIADH) IV Laboratory Investigation and Differential Diagnosis 12. SPINAL FLUID AND OTHER LABORATORY FINDINGS CSF PROTEIN CSF CELLS ROUTINE LABORATORY FINDINGS 13. ELECTROPHYSIOLOGIC STUDIES With the assistance of Dr. Bhagwan Shahani PATTERNS OF ELECTROPHYSIOLOGIC ABNORMALITIES Motor Nerve Conduction Block Proximal Conduction Block Intermediate Conduction Block Distal Conduction Block Slowed Nerve Conduction Velocity EMG and Patterns of Axonal Damage Acute Axonal GBS CHANGES IN ELECTROPHYSIOLOGIC FINDINGS OVERTIME ANCILLARY ELECTROPHYSIOLOGIC STUDIES Blink Reflexes Brainstem Evoked Potentials Visual Evoked Potentials Somatosensory Evoked Potentials Sympathetic (Galvanic) Skin Response and RR ECG Interval Phrenic Nerve Conduction PROGNOSTIC ELECTROPHYSIOLOGIC FEATURES ELECTROPHYSIOLOGIC STUDIES IN EARLY GBS: THE MGH PROSPECTIVE STUDY Motor Nerve Abnormalities Sensory Nerve Abnormalities EMG Relation of Electrophysiologic Features to Clinical Variants Follow-up Studies Ancillary Studies (Blink Reflex, SSR, RR Interval) Outcome Related to Electrophysiologic Studies 14. DIFFERENTIAL DIAGNOSIS DIFFERENTIAL DIAGNOSIS BASED ON CLINICAL SIGNS Asymmetric Limb Weakness Asymmetric Sensory Loss Asymmetric Cranial Nerve Weakness Facial Sensory Abnormalities Prominent Sensory Abnormalities Prominent Ataxia Pure or Predominantly Motor Symptoms and Signs Prominent Pain CSF Pleocytosis Increased CSF Protein Differential Diagnosis of Fisher s Syndrome Internal Ophthalmoplegia External Ophthalmoplegia Ptosis Respiratory Failure Disproportionate to Limb Weakness Prominent Oropharyngeal Paralysis Constipation and Ileus Nausea, Vomiting, and Abdominal Pain Dry Mouth or Eyes Abnormal Mental Status Seizures Fever Mucocutaneous Abnormalities Postoperative or In-Hospital Onset Travel and Geographic Considerations Underlying Cancer Hypokalemia MAJOR DISEASES SIMULATING GBS Spinal Cord Disorders Myasthenia Gravis Antibiotic-Induced Paralysis Lambert-Eaton Myasthenic Syndrome Polymyositis Other Ac.