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Zustand: As New. Like New condition. A near perfect copy that may have very minor cosmetic defects.
Verlag: Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Buch
Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Verlag: Birkhäuser Boston, 2012
ISBN 10: 1461286603ISBN 13: 9781461286608
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Buch
Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Springer Book Archives.
Verlag: Birkhäuser Boston, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Buch
Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume reviews the new potential treatments and research in the area of Alzheimer's disease. Special attention is given to international developments in all fields relevant to new drug development. Topics discussed include: progress in the international harmonization of drug development guidelines for dementia drugs; bioethics and law; development of rating instruments; behavioural treatments; and the activities of the Reagan Foundation. The text integrates basic and clinical research findings, and provides evaluation of new approaches to therapy by world leaders in the field. The potential benefit for Alzheimer patients and families resulting from these research programmes, from molecular biology to clinical pharmacology, is reviewed and evaluated.
Verlag: RAVEN PRESS, New York, 1970
Anbieter: Between the Covers-Rare Books, Inc. ABAA, Gloucester City, NJ, USA
Erstausgabe
Hardcover. Zustand: Near Fine. First edition. Volume 2 only. Near fine without a dustwrapper.
Verlag: CRC Press 2006-04-19, London, 2006
ISBN 10: 1841845752ISBN 13: 9781841845753
Anbieter: Blackwell's, London, Vereinigtes Königreich
Buch
hardback. Zustand: New. Language: ENG.
Verlag: Informa healthcare, 2006
Anbieter: Librodifaccia, Alessandria, AL, Italien
Zustand: Buone. inglese Condizioni dell'esterno: Buone Condizioni dell'interno: Buone.
Verlag: Birkhäuser Boston, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Anbieter: moluna, Greven, Deutschland
Buch
Gebunden. Zustand: New.
Verlag: Birkhäuser Boston, 2012
ISBN 10: 1461286603ISBN 13: 9781461286608
Anbieter: moluna, Greven, Deutschland
Buch
Zustand: New.