Donath

Donath, W.F. A FINE AND INTERESTING COLLECTION OF THE WORK DONE BY DONATH, B.C.P. JANSEN AND C. EYKMAN REGARDING THE ISOLATION OF VITAMINE B1.

1926. -1927. The collection is brought together by DONATH the physician WHO ISOLATED VITAMINE B1 in BUITENZORG (now Indonesia). Most of the colllection is mounted in a contemporary album. Folio. Mainly 1926 - 1927. (The first description of the isolation of Vitamine B1 was in 1926 see G. &.M.no. 3746). The collection consist of the following items. I. Photographs: 1. orig. photograph of Donath, Jansen and Soedartono outside the laboratory. 2. the office were the Vit.B1 has been isolated. again with Donath and Jansen and the Indonesian staff. 3. the room in which the rats were breed. (same persons) 4. photograph of the vit.B. stand at the 1e Nl. Hygiene tentoonstelling te Bandoeng. (all these are mounted) .Loosely inserted are 5 other photographs (2 duplicates) one other orig. photograph of the rat room. ( with Donath and Jansen). A photograph of probably the farewell dinner for Donath. A portrait of an Indonesian Scientist. II:Press-cuttings. 85 orig. press-cuttings mainly reflecting the isolation of vitamine B1. Some on Donath and Eijkman. and 20 loosely inserted press-cuttings on the same. III: Letters. A typoscript transcription of a letter by Eykman to Jansen. A telegramm by Ruys. 9 transcription of letters to B.C.P. Jansen in the handwritting of Donath. ( Letters by a.o. K.H.A.Plmmer, W.Weitzel, P. Zjorgy. P.Karrer (The Nobel-Prize Winner). Vogel. E.C.Kendall and H.C.Sherman. 1 Menucard for the 4th. Nl._Ind. Nat.Wet. Congres. (mounted) IV: Transcriptions in handwritting by Donath of the following papers. By W.J.Bair. (In Trop. Dis. Bull.). by Meier in Chemis Zentralblatt. by C. Eykman in Kon. Ak. v. Wet. by Kurten in Ber. über die gesam. Biol. by Kirscher in Archiv für Schiffs- und Tropenhygien. by. M.S.Barr in Brit. Chem. Abstr. by Hermans in Pharm. Tijdschrift. by Vrijling in Tijdschr. v. Diergeneeskunde.by Whittinham (Trop. Dis. Bull.) and some 5 others. V : Loosely inserted are the following letters. A letter by Welter. dated 1 oct. 1932. (A.L.) . 8 pp. letter from Donath for his mother and sister.(Orig. handwrit.) dated 30/11/1928. 4 page orig. letter in handwrit. by Donath to Dr. Stoffel. Dated 4 Jan 1927. Orig. letter dated 24/11/27 by H. Zwaardemaker to Donath. (1 p.) orig. letter (2 p.) dated 14/12/1927 by H. Zwaardemaker to Donath. (Signed). Orig. handwr. letter by Donath to Dr. Bernard dated 24/4/29. A letter by G.A. de Stoppelaar in handwrit. and sign. dated 20/8/33. A Letter by A.C. de Jong van Wassenaar in handwr. dated 23/8/33. and signed. A 1 p. manuscipt with chemical analysis signed Soepad in handwrit. A Letter to Nieuw van de Dag. by Donath.(Handwritten). 2 p. handwritten letter and signed by Donath. A typoscript letter by C. Eykman signed and dated 25/1/28 to Donath. another typoscript letter signed and dated 24/5/97 to Donath by Eijkman., and 3 other signed typoscript letters. 2 printed invitations and 1 telegramm. Mounted in is one orig first ed. offpr. by Eijkman in which he discusses the work done by Donath and Jansen. A very fine collection reflecting the isolation of Vitamine B1 in scientific periodicals and in original and transcriptions of letters. All brought together by Donath with nummerous annotations in his hand. Of special importance are of course the two typoscript letters by Eijkman (signed and dated.) An authority on the subject on winner of the NOBEL-PRIZE for his vitamin and Beri-Beri Research. KEYWORDS: physiology tropical medicine/science vitamins nobel-prize winners Indonesia

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Donath, Julius & Landsteiner, Karl: Ueber paroxysmale Hämoglobinurie (pp.1590-1593, 1 Tab.). MMW, 51/36. - München, J.F. Lehmann, 6. September, 1904, 4°, pp.1585-1632, feiner Halbleinenband.

First Print of the "first description of an auto-antibody, and of an auto-immune disease, paraoxysmal cold hemoglobinuria" by Julius Donath (1870-1950) and Carl Landsteiner (pp.1868-1943)

Paroxysmal cold hemoglobinuria - "This fairly rare disease is characterized by the acute intravascular destruction of red cells with a resulting hemoglobinuria, after exposure of the patient to the cold. The pathogenesis of the disease was unknown until 1904, when Viennese clinician Julius Donath suggested that the cause of the disease is due to the formation of autoantibodies against the patient's own erythrocytes12. To further support his thesis, Donath enlisted the aid of Karl Landsteiner, with whom he had previously collaborated on other studies. Landsteiner was already a well-established investigator, who had earlier discovered the ABO blood group system of man13 (for which he received the 1930 Nobel Prize in Physiology or Medicine). With Donath providing the patients and Landsteiner the laboratory know-how, they attacked the problem together.
The investigations proved to be both simple and conclusive because the principle feature of the disease could be reproduced in vitro. Blood from the affected patients was collected in oxalate, the plasma was separated and the red cells washed. Mixing the two at room temperature had no effect, but mixing them in the cold and then rewarming the mixture resulted in massive hemolysis. When the washed cells alone were subjected to the same temperature change, nothing happened, which indicated that it was something in the plasma that was responsible for the hemolytic event. When the plasma alone was cooled, rewarmed and then added to the patient's washed erythrocytes, again nothing transpired, which suggested that the two reagents must interact in the cold before rewarming. However, when the plasma was heated to 56 °C before use in the above tests, no hemolysis occurred, which indicated that some plasma participant in the reaction is thermolabile. This labile activity, however, could be replaced by any active (that is, unheated) serum or plasma from normal individuals, which suggested that whatever the thermolabile factor is, it is not peculiar to this disease. These experiments were followed up by testing patients' plasma against the red cells of normal controls, and patients' red cells against the serum or plasma of normal controls, using the same protocol as before. The result was clear: some thermostable substance in the plasma of the patient could lyse any human erythrocytes, whereas the red cells of the patient could not be destroyed by the plasma of control individuals.
The only interpretation possible was that three components are involved in the process: red cells, a thermolabile factor and a thermostable factor. Only the thermostable factor appeared to be abnormal and to exist only in the patients' blood because the other two factors (red cells and unheated serum) could be furnished by normal controls. This finding was elegantly confirmed as follows: the patient's plasma was cooled in the presence of a large amount of washed, normal human red cells, which were then centrifuged and set aside. New cells were then added and the mixture warmed. No hemolysis resulted, which indicated that the active substance had been removed specifically by the initial treatment. However, the cells used for the absorption could then be lysed in the warm on the addition of an unheated serum, which showed that they had indeed interacted with (absorbed) the active substance. When a control was run under the condition where the initial mixture was maintained in the warm, it was found that no absorption of the active substance had taken place. Here was an interaction of active substance with erythrocyte that could occur only in the cold!
It was clear to the investigators that the hemolysis that takes place in the blood of the hemoglobinuric patient follows the general rule for immune hemolysis that had been laid down by Bordet and confirmed by Ehrlich and Morgenroth. The interaction of an antibody to erythrocytes with its target cell, followed by a dissolution of the cell, is mediated by the thermolabile substance that Bordet called alexine and Ehrlich called complement. Here was an incontrovertible demonstration of the apparently spontaneous formation of a toxic autoantibody, although admittedly a strange one in that it only attached to the target cell in the cold, whereas complement only acts when the sensitized cells are rewarmed. The pathogenesis was now clear, although the etiology remained an open question; most cases appear to be associated with a pre-existing syphilis infection. Horror autotoxicus had just received an apparently lethal challenge." A.M. Silverstein, Autoimmunity versus horror autotoxicus: The struggle for recognition , NATURE IMMUNOLOGY 2 (4): 279-281 APR 2001 See: The Donath-Landsteiner Autoantibody: The Incommensurable Languages of Immunoligcal Dispute. Silverstein, Hist. Imm., pp.190-213
Garrison Morton No.2558.1; Milestones in Immunology

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Donath, Hen [Hrsg.]: Marienkirche Hanau : Festschrift 1984, Hanau : Selbstverl. d. Kirchenvorstandes d. Marienkirchengemeinde, 1984.
Der Chorbau der Marienkirche im Zusammenhang mit dem frommen Erleben und der politischen Gestaltung der Welt Hen Donath 4 - Spätgotische Glasmalerei - Bilddokumentation und Beschreibung - Dr. Suzanne Beeh-Lustenberger und Karl Heinz Doll (Fotos) 14 Die rechtliche Stellung und wirtschaftliche Bedeutung der Kirche im Mittelalter - ein Überblick zur Orientierung - Dr. Wolfgang Haseloff 31 Die Zeit der Reformation in Hanau Heinz Kurz 32 Köpfe der Reformation an der Marienkirche in Hanau O Julius Martiny 38 Lebendige Geschichte aus Tagebüchern des Lebens und Sterbens Heinz Kurz und Hen Donath 39 Hanau-Münzenbergische Kirchen-Stuhl-Ordnung 43 Glocken, Turm und Grabstätten Werner Jacob 50 Ein Begräbnis im Jahre 1760 Dr. Eckhard Meise 55 Vom Siebenjährigen Krieg bis zum Vormärz - Drei Generationen einer Pfarrerfamilie an der Marienkirche - Dr. Friedrich Wilhelm Schluckebier 57 Die Hanauer Union seit 1818 Julius Martiny 61 Freiheit und Einheit - Porträt des Sprengels Hanau - Dr. Friedrich Wilhelm Schluckebier 68 Kindheit und Jugendzeit in der Nachbarschaft der Marienkirche - Ausgewählte Erinnerungen von Dr. Heinrich Bott - Hen Donath 72 Viel zu wenig wurde davon gesagt und geschrieben . . . - Ein Beitrag zur jüngeren Hanauer Kirchengeschichte - Hen Donath 78 Phasen des Wiederaufbaus in Bildern Hen Donath 102 Zwanzig Jahre Pfarrerin an der Marienkirche Elisabeth Specht 110 Musik als fester Bestandteil des Gemeindelebens Gerhard Holzner 114 Die Orgeln der Kirche Gerhard Holzner 117 Die Evangelische Marienkirchengemeinde in der Hanauer Innenstadt Frank-Peter Hopf 118 Die Martin-Luther-Stiftung als Seelsorgebereich der Marienkirche Karl Kleem 121 Die ökumenische Telefonseelsorge Main-Kinzig Thomas Weil 124 Z16360I8 - Lieferungen außerhalb Deutschlands nur gegen Vorkasse * TÄGLICHER VERSAND (Montag-Freitag) *

kart., 124 S. : Ill. ; 30 cm, guter / sehr guter Zustand

[SW: Hanau am Main, Kirche, Kirchen, Religion, Festschrift, Jubiläumschrift, Kirchengeschichte, Hessen, Evanglische Kirche]

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Donath, Adolph (Hrsg.): Der Kunstwanderer. Konvolut 1922 - 1923 Halbmonatsschrift für Alte und Neue Kunst für Kunstmarkt und Sammelwesen. Konvolut von 13 (in 11 Heften des 3. - 5 Jahrgangs, September 1922 bis August 1923. Mit Beiträgen von Ernst von Bassemann Jordan, Julius Baum, Elfried Bock, Wilhelm Bode, G. A. E. Bogeng, Edmund Wilhelm Braun, Ernst Collin, Ludwig Darmstädter, Adolph Donath, Max J. Friedländer, Gustav E. Pazaurek, Hermann Schmitz, Philipp Schweinfurth, Hans W. Singer, Wilhelm Waetzold, Franz Weinitz, Konrad Weiß und anderen. Berlin-Schöneberg: Verlag der Kunstwanderer, 1921 -.
Adolph Donath (1876-1937) zählt mit seinen Arbeiten und der von ihm herausgegebenen Zeitschrift 'Der Kunstwanderer' zu den bedeutendsten Kunsthistorikern und -kritikern in der Weimarer Republik . Umschläge teils angestaubt, Klammern angerostet, sonst ordentlich erhaltenes und gut brauchbares Exemplar. - * * * Achtung * * * Wichtiger Hinweis * * * Anfragen und Bestellungen, die ab Samstag, dem 07. 04. 2012, eingehen, können spätestens ab Montag, dem 16. 04. 2012, bearbeitet werden ! ! !

504 (4) Seiten mit zahlreichen Abbildungen. 32 x 24,5 cm, Original-Umschläge mit Deckeltitel.

[SW: Adolph Donath Weimarer Republik Kunst Kunstmarkt Sammelwesen Wilhelm Bode, Ludwig Darmstädter, Adolph Donath,]

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