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Interindividual Variability in Human Drug Metabolism.

Pacifici, Gian Maria [Ed]; Pelkonen, Olavi

Verlag: Taylor & Francis, London, 2001
ISBN 10: 0748408649 / ISBN 13: 9780748408641
Gebraucht / Hardcover / Anzahl: 1
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Titel: Interindividual Variability in Human Drug ...

Verlag: Taylor & Francis, London

Erscheinungsdatum: 2001

Einband: Hardcover

Zustand: Very Good

Beschreibung:

400p Hardcover, this is almost a new copy without any traces of use, cover a bit dusty perhaps, never used, without fault. Buchnummer des Verkäufers PAB 62816

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Inhaltsangabe: The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.

Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

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