Three families of CYPs in the human cytochrome P450 (CYP) gene superfamily, imaginatively called CYP1, CYP2, and CYP3, account for more than 90% of the oxidative metabolism of clinical drugs. CYP2D6, although only 2-4% total hepatic CYP, metabolizes about 25% of all medications in the human liver. Clearly, this "David" does "Goliath" work. This book reviews what is currently known of the structure, function, regulation, and polymorphism of CYP2D6. It review the maturing body of evidence indicating that CYP2D6 should be of interest to clinicians, pharmacists, pharmaceutical scientists, and pharmacologists.
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