Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

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9780470569061: Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

I could recommend Rosenbaum s book for pharmacology students because it is written from a perspective of drug action ... Overall, this is a well-written introduction to PK/PD that may fill a small niche in a well-served market. (British Toxicology Society Newsletter, 1 June 2012)"In summary, I believe that this book is successful in what it sets out to do. For those readers who are interested in getting to grips with the basics of the time course of onset, offset and extent of drug effects then this is the book for you. I am certainly recommending this book for my graduate students." (British Journal of Clinical Pharmacology, 2011)

"A readable font size, good quality paper and a stout binding make this an excellent offering ... This is an ideal textbook for those starting out on the pharmacokinetic trail and also for use as a reference book for those who delve occasionally into this subject." (International Society for the Study of Xenobiotics, 1 April 2012)

"In short, this is a thorough and well-designed presentation and development of key concepts in pharmacokinetics and pharmacodynamics. It is a very useful textbook, and one that I would be comfortable using in both medical and graduate teaching." (Doody's, 21 October 2011)

Vom Verlag:

With its clear, straightforward presentation, this text enables youto grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self-study.

By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory-level textbooks in this area.You'll find severalfeatures throughout the text to help you better understand andapply key concepts: *

Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles *

Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems *

Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses

Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you'll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

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